The use of DMSO for destroying adipocytes & eliminating cellulite/adiposities

Most women, i.e. more than 99%, have or will have cellulite and, despite the fact this problem leads to a disease with low clinical implications, it brings great aesthetic concern, many times leading to constraint while using small clothes or bathing suits, being main consequences of cellulite of aesthetic order, with impairment of self-esteem and social interactions, especially when in advanced stages, not to mention the health problems inherent to it, of course.

The excess of localized fat present in several parts of the female and male body is also cause of anguish and, as well as cellulite, cause of a number of issues such as low self-esteem, dismay, depression and impaired social interactions.

According to World Health Organization (WHO), there are more than 1.1 billion overweight adults and 300 million obese adults.

Since it increases the risk of diabetes, arterial hypertension, heart diseases, joint diseases, psychiatric disorders, and certain forms of cancer, WHO considers obesity as one of the world’s ten main threats to health integrity and one of the five main in industrialized countries.

According to studies from competent bodies, the number of obese people increases every day. For example, researches show there are about 17 million obese people in Brazil, which means 9.6% of the population.

The effects of the obesity along with modern life’s stress, poor diet, sedentary life and lack of mental and physical balance can be devastating to human body.

According to recent researches, the adipocytes (fat cells) proliferate since birth until a certain age, more specifically until 20 years of age. People with normal weight accumulate 20-30 billion adipocytes, while obese people have 60-80 billion of such cells.

Every year, regardless one’s weight, 10% of the fat cells die. However, they are replaced by younger cells with more need of fat.

After the twenties, the number of adipocytes is kept, they only swell or increase in size when the person grows fat, and shrivel or decrease in size if the person loses weight. When swollen, adipocytes are filled with fat and cause a number of consequences, such as obesity, the onset of the well-known cellulite and adiposities (localized fats), besides all heart and metabolism problems deriving thereof, of course.

This is the reason why it is so difficult to lose weight and keep shape and why the harmful “yo-yo effect” occurs, i.e., alternating weight gain and loss resulting from consecutive diets to lose weight.

There is fat inside an adipocyte. When a person is in a calorie-restricted diet, the cell size is reduced, but that cell is not eliminated. Therefore “weight loss” occurs.

Fat cells constantly diminished effectively result in weight loss and reduction of body measures. However, once calories are back those cells quickly grows back to same size or even larger. That is, a person can become even fatter than before starting the diet.

Several signals and symptoms have been related to what is referred to as “cellulite”, which makes difficult for the understanding and therapeutically guidance regarding the pathology, especially for those with no skills in the art: thus, it is described as accumulation of fat tissue (fat cell+cell rancidity) in certain sites (being confused with lipodystrophy) or even as an exclusively dermal process.

For those with no skills in the art, cellulite belongs to the field of localized obesity, with an aspect of adipose hypertrophy characteristically edematous, followed by well-known alterations to skin appearance (“orange peel skin”), notably on hips and thighs.

Hardly dissociated from obesity, to which is often connected, cellulite features more complex pathogenic issues, and the term should be saved for superficial infiltrations, either localized or generalized. Whatever are the ways cellulite is developed, it looks like some initiating factors interfere by means of a circulatory vasomotor disturbance in connective tissues which entraps a critical vasculature and sensitive innervations at the same time.

Briefly, cellulite is the accumulation of fluid, fat and water in tissues, forming localized bags attached to a net of adherence and sclerotic tissues that would cause changes to local blood circulation and tissue oxygenation, thus forming the “orange peel skin” appearance.

Cellulite is accepted as an autonomous anatomic and clinical entity, different from obesity or lipodystrophy; however, it is commonly associated to both.

With peculiar clinical and etiopathogenic characteristics, cellulite often requires a wider approach, involving psychological, biological, and sociological aspects.

Psychological and social concerns around cellulite are complex and hard to approach; there are no purely psychosomatic implications and patient\’s complaints are not supposed to be taken as mere aesthetic concerns, since it often reflects an enormous anxiety.

There is this permanent and insistent pressure to fit in the utopic representation depicted on the cover of female magazines: the lean-shaped figure who wants and gets all men; powerful, free, and perfect.

Fashion is constrained to beauty. Its language turns women\’s bodies into objects that consume and are consumed.

As long as the psychological and social concerns around cellulite are discussed, its complexity and difficult theoretical approach must not be ignored.

More than thirty pharmacological and therapeutic properties have been found for DMSO, which result from its ability to interact or combine with nucleic acids, carbohydrates, lipids, proteins and many drugs without irreversibly changing the molecular configuration. These properties assure its acknowledgment as one of the most versatile drugs ever known.

On the other hand, since its introduction as medicine, DMSO has generated controversy in the scientific environment, dividing opinions, since its evaluation is extremely difficult due to the numerous and complex variables involved, especially when blended to other actives, since DMSO is a powerful active diffuser.

DMSO is one of the most powerful antioxidants or inhibitors of hydroxyl free radicals, with the advantage of being usable topically, orally and/or via parenteral, with almost no side effects. Priority (known) intended uses of DMSO are related to musculoskeletal pathologies, of degenerative, inflammatory, and/or traumatic nature.

Among the intended uses and properties described in literature, it could be mentioned the topical application for musculoskeletal diseases; topical inflammatory agent; topical pain reliever; itch reliever; skin problems; vasodilating effect; rheumatoid arthritis; penetrating and diffusing effect; carrier of other drugs, potentializing effect of other substances; herpes zoster; slight bacteriostatic agent; macular and papular amyloidosis; scleroderma; improves blood circulation to all tissues; muscle relaxant; immunomodulatory action; increases cell function and differentiation; cryoprotective action; calming effect.

The application is systemically administered for rheumatic diseases, gastrointestinal disorders; cerebral edema(traumatic); diuretic; interstitial cystitis; vasodilating effect; urinary problems; lung problems; action on lipid metabolism; lung adenocarcinoma; chronic prostatitis; schizophrenia; Alzheimer\’s disease; antagonism of platelet aggregation; protection against ischemic injury.

For all these reasons, the Applicant, being active in the market and always concerned with the evolutions of his/her products, with the objective of always offering the best for the consuming public, has already filed with INPI [Brazilian Institute of Industry Property], Patent Application no. PI0504655-6, filed on Oct. 17th, 2005, entitled “DMSO BASED FORMULATIONS FOR USE IN FIGHTING CELLULITE AND OTHER ADIPOSITIES”, which describes the use of DMSO-based formulations to locally fight body adiposities, these being: paniculopathy edemofibrosclerosis, localized fats; flabbiness; and fat in general; such formulations use different percentages of DMSO in different solutions, these being: gel, cream, aqueous solution and solution for mesotherapy.

Said patent no. PI0504655-6 is based in using DMSO to fight cellulite and other adiposities, i.e., since cellulite is mainly characterized by the presence of rancid, ill-nourished, poorly oxygenated fat, with accumulation of toxins, besides other factors contributing to its formation, the researches made to reach to a definitive solution for the problem come upon not only fighting the cellulite, where there is only an improvement from the “orange peel skin” appearance, but in eliminating the problem, i.e., it is not about palliatives anymore, but a definitive solution for the problem.

It is correct to say that, regarding the destruction of adipocytes, which are also present in cellulite, it is also considered using DMSO to eliminate adiposities (localized fats), since destroying fat cells naturally eliminates adiposities.

By destroying an approximate amount ranging from fifty thousand (50,000) to five-hundred thousand (500,000) adipocytes (fat cells) per delivery of DMSO, fat cells (adipocytes) are effectively destroyed. The “rancid” fat cells (adipocytes) generate the cellulitic nodule. Eliminating the adipocyte (fat cell) will eliminate cellulite and consequently the adiposity.

Many denominations have been proposed over the years for cellulite, such as panniculitis, panniculosis, lipedema, mesenchimatosis, fibro edema geloid, panniculopathy, etc.

Despite of the diversified nomenclature, all authors agree in several essential, constant aspects in cellulite, that is, it affects most women; it is localized in very specific areas; it is frequently associated to lipodystrophy or obesity; it is caused by a hydric unbalance due to the polymerization of mucopolysaccharides; interrupted or hindered intercellular diffusion; changes in microcirculation.

Cellulite, despite of the inadequate term, constitutes an autonomous anatomic and clinic entity.

It is a dysmorphia related to a dystrophy localized in cutaneous connective tissue and subcutaneous adipose tissue, which hypertrophies. Both parameters, cutaneous and adipose, are affected at various levels.

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