{"id":371,"date":"2015-10-02T12:38:05","date_gmt":"2015-10-02T12:38:05","guid":{"rendered":"http:\/\/simpletruths.me.uk\/?p=371"},"modified":"2016-07-31T01:48:26","modified_gmt":"2016-07-31T01:48:26","slug":"pubmed-antitumour-activity-of-colloidal-silver","status":"publish","type":"post","link":"https:\/\/simpletruths.me.uk\/?p=371","title":{"rendered":"PubMed: Antitumour activity of colloidal silver"},"content":{"rendered":"<div class=\"abstr\">\n<div class=\"\">\n<h4><a href=\"https:\/\/simpletruths.me.uk\/wp-content\/uploads\/2015\/10\/pubhead.gif\"><img loading=\"lazy\" decoding=\"async\" class=\" size-full wp-image-372 aligncenter\" src=\"https:\/\/simpletruths.me.uk\/wp-content\/uploads\/2015\/10\/pubhead.gif\" alt=\"pubhead\" width=\"456\" height=\"60\" \/><\/a><\/h4>\n<h4>BACKGROUND:<\/h4>\n<p>Colloidal silver has been used as an antimicrobial and disinfectant agent. However, there is scarce information on its antitumor potential. The aim of this study was to determine if colloidal silver had cytotoxic effects on MCF-7 breast cancer cells and its mechanism of cell death.<\/p>\n<h4>METHODS:<\/h4>\n<p>MCF-7 breast cancer cells were treated with colloidal silver (ranged from 1.75 to 17.5 ng\/mL) for 5 h at 37\u00b0C and 5% CO2 atmosphere. Cell Viability was evaluated by trypan blue exclusion method and the mechanism of cell death through detection of mono-oligonucleosomes using an ELISA kit and TUNEL assay. The production of NO, LDH, and Gpx, SOD, CAT, and Total antioxidant activities were evaluated by colorimetric assays.<\/p>\n<h4>RESULTS:<\/h4>\n<p>Colloidal silver had dose-dependent cytotoxic effect in MCF-7 breast cancer cells through induction of apoptosis, shown an LD50 (3.5 ng\/mL) and LD100 (14 ng\/mL) (*P &lt; 0.05), significantly decreased LDH (*P &lt; 0.05) and significantly increased SOD (*P &lt; 0.05) activities. However, the NO production, and Gpx, CAT, and Total antioxidant activities were not affected in MCF-7 breast cancer cells. PBMC were not altered by colloidal silver.<\/p>\n<h4>CONCLUSIONS:<\/h4>\n<p>The present results showed that colloidal silver might be a potential alternative agent for human breast cancer therapy.<\/p>\n<p>&nbsp;<\/p>\n<p>Click <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21080962\">here<\/a> to read the pubmed webpage that this article appeared on.<\/p>\n<p>Click <a href=\"https:\/\/simpletruths.me.uk\/?post_type=product\">here<\/a> to purchase the STF Complete Colloidal Silver Generator kit.<\/p>\n<p>Click <a href=\"https:\/\/simpletruths.me.uk\/?p=23\">here<\/a> to learn how to put a simple colloidal silver generator together.<\/p>\n<p>Click <a href=\"https:\/\/simpletruths.me.uk\/?p=312\">here<\/a> to see the shopping list of components.<\/p>\n<p>Click <a href=\"https:\/\/simpletruths.me.uk\/?cat=8\">here<\/a> to see all the posts regarding colloidal silver on this blog.<\/p>\n<p>Click <a href=\"https:\/\/www.facebook.com\/groups\/csilversuccess\/\">here<\/a> for the Colloidal Silver Success Stories Facebook group.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>BACKGROUND: Colloidal silver has been used as an antimicrobial and disinfectant agent. However, there is scarce information on its antitumor potential. The aim of this study was to determine if colloidal silver had cytotoxic effects on MCF-7 breast cancer cells<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/simpletruths.me.uk\/?p=371\">Read more &#8250;<\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":9855,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-371","post","type-post","status-publish","format-standard","hentry","category-colloidal-silver"],"_links":{"self":[{"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=\/wp\/v2\/posts\/371","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=\/wp\/v2\/users\/9855"}],"replies":[{"embeddable":true,"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=371"}],"version-history":[{"count":3,"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=\/wp\/v2\/posts\/371\/revisions"}],"predecessor-version":[{"id":796,"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=\/wp\/v2\/posts\/371\/revisions\/796"}],"wp:attachment":[{"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=371"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=371"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/simpletruths.me.uk\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}